?????????????? ????? ?????????????! ??????????????????????????? ?????????????????????????????
????????????????????????? ????? ??????????????????????????????????????????????????????????????????????????????????????????????? ????????????????????????????????? ?????????????????????????????????????????????????
?????????????? ???????????????????????????????????????????? ??????????? ?????????????????????????????????????????? 5 – 10 % ??????????????????????????????????????????????????? ????????????????????????? ????????????????????? ???????????????? ???? ????? ????? (Bio ink Co., Ltd.) ????????????? (spin-off) ???????? ?????????????????????????????????????????????????? ????????????????????????????????????????????????????? ????????????????????????????????? ?????????????????????????????????????????????????
????????????????? ????????????????? ?????
“?????????????????????????????????????????????????????????? ????????????????????????????????????????????????????????????? ???????? ???????????????????????????????????????????????????????????????????? ????????????????????????????????????????????????????” ?????????????????? ???????????? ??.????? ???????? ????????????????? ????????????????? ????? ??? co-founder ????????? ???? ????? ????? ???????????????????????????????????????????????????????????????????????
“?????????????????????? ??????????? ????????????????????????????????????????????????????????????????????? ???????????????????????????? ????????????????????????????????????????????????? ????????? ?????????????????????????????????????????????? ?????????????????????????????????????????????????”
????????????????????????????????????????
??.?.??.??.????? ?????????????????????????????????????????????????????????????? 1 ??????????????? beta-cells ????????????????????????????????????? ?????????????????????????? ?????????????????? 2 ??????????????????????? ???????????? beta-cells ?????????????????????????????????? ????????????????????????????????? ?????????????????????? 2 ????????????????????????
??????? ????????????? ??.????????? ???????? ??? ??.????????? ??????????? co-founder ?????? ???? ????? ????? ???????????????????????? ?????????????????????? ?????????? Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC) ????????????????? ????? ????????? ???? ????? ????? ???????????????????????????????????? 1 ?????????????????? ???????????? ????????????????????????????????????????????????????????????????????????????????????????????????????
“?????????? ???????????????????????????? ??????????????? ??????????????????????? (insulin-producing cells, IPCs) ???????????????????????????????????????????????????????????????????? (canine mesenchymal stem cells, cMSCs) ?????????????????????????????? ?????????????????????????????????????????????????????? ????????????????????? ???????????????????????????????????????????????????????????”
??.????????? ???????????????????????????????????????????????????????????????????????????????????????????? double encapsulation ????????????????? ??????????????????????????????????? ??????????????????????????????????????????
“????????????????????????????????????? ??????????????????????? 10 ????????????????????????????????????????????????????????????????? ???????????????????????????????????????????????????????????????????????? ???????????????????????????????? ??????????????????????????????????????????????? ?????????????????????????????????????????????????? ??????????????????????????????????????”
?????????? ???????????????????????????????
???????? ???????????????????????????????????????????????? ???????????????????? ???????????????? ??????????????????????????????????????????????????? ????????????????????????? ?????????????????????????????????????????????????????????????????? ??????????????????????????????????????? ????????????? 3 ???????????????????????????????????????????
“????????????????????????????????????????????? ???????????????????????????????? ?????????????????????????????????????????????????????????????????????????????? ????????????????????????????????????????????????????????????????????????????????????????????????????????? ??????????????????????????????????????????????????????????? ???????????????????? ?????”
??.?.??.??.????? ????????????????????????????????????????????????????????????????????????? ????????????????????????????????????????????????????????????????????????????????????
????????????????????????????????????????????
?????????????????????????????????????????????????????????? ?????????? VSCBIC ????????????????? ????? ????????? ???? ????? ????? ??????????????????????????????????????????????????????? (cell therapy) ????????????????????????? (stem cell-derived products) ????????????????????????????????????????????????? ???? ???????????????????????????????????? Exosome Product ??????????????????????????????????????????????????????????????????????????????????? ????????????????????????????????????????????????????????????????? ????????? ????????????????????????????????? ???? ????????? ?????? ????? ??????????????????????????????????? ??????????? ????????????????????? ???????????????????????????????????????? ?????????? 2 ?? ???????????????????????????????????????????????????????????
?????????????? ????
References
- Quynh Dang Le., Watchareewan Rodprasert., Suryo Kuncorojakti., Prasit Pavasant., & Chenphop Sawangmake. (2021). In vitro generation of transplantable insulin-producing cells from canine adipose-derived mesenchymal stem cells. Scientific reports, 2022 (9127), 12.
- Suryo Kuncorojakti., Watchareewan Rodprasert., Quynh Dang Le., Thanaphum Osathanon., Prasit Pavasant., & Chenphop Sawangmake. (2021). In vitro Induction of Human Dental Pulp Stem Cells Toward Pancreatic Lineages. Journal of Visualized Experiments, 2021(175), e62497.
- Watchareewan Rodprasert., Sirirat Nantavisai., Koranis Pathanachai., Pavasant, P., Thanaphum Osathanon., & Chenphop Sawangmake. (2021). Tailored generation of insulin producing cells from canine mesenchymal stem cells derived from bone marrow and adipose tissue. Scientific reports, 11(1), 1-17.
- Suryo Kuncorojakti., Watchareewan Rodprasert., Supansa Yodmuang., Thanaphum Osathanon., Prasit Pavasant., Sayamon Srisuwatanasagul., & Chenphop Sawangmake. (2020). Alginate/Pluronic F127-based encapsulation supports viability and functionality of human dental pulp stem cell-derived insulin-producing cells. Journal of Biological Engineering, 14(1), 1-15.
- Chenphop Sawangmake., Watchareewan Rodprasert., Thanaphum Osathanon., & Prasit Pavasant. (2020). Integrative protocols for an in vitro generation of pancreatic progenitors from human dental pulp stem cells. Biochemical and Biophysical Research Communications, 530(1), 222-229.
- Suryo Kuncorojakti., Sayamon Srisuwatanasagul., Krishaporn Kradangnga., & Chenphop Sawangmake. (2020). Insulin-producing cell transplantation platform for veterinary practice. Frontiers in Veterinary Science, 7, 4.
- Chenphop Sawangmake., Nunthawan Nowwarote., Prasit Pavasant., Piyarat Chansiripornchai., & Thanaphum Osathanon. (2014). A feasibility study of an in vitro differentiation potential toward insulin-producing cells by dental tissue-derived mesenchymal stem cells. Biochemical and biophysical research communications, 452(3), 581-587.
